Brain natriuretic peptide (1-32) (human)
Biological ActivityBrain natriuretic peptide (1-32) (human) is an endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo.
(Modification: Disulfide bridge: 10-26)
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Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases.
Tsuruda et al.
Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo.
Wellard et al.
Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various forms of human B-type natriuretic peptide.
Heublein et al.
Citation for Brain natriuretic peptide (1-32) (human)
The citations listed below are publications that use Tocris products. Selected citations for Brain natriuretic peptide (1-32) (human) include:
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GDF15 is a heart-derived hormone that regulates body growth.
Authors: Wang Et al.
EMBO Mol Med 2017;9:1150
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Used in vitro to investigate different roles of NP family members.