Catalog Number: 2177
Biological Activity
Highly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4 receptors.
Technical Data
  • M.Wt:
    1221.46
  • Formula:
    C58H92N16O13
  • Sequence:
    INPIYRLRY

    (Modifications: Tyr-9 = Tyr-OMe)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    262418-00-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity.
    Jois and Balasubramaniam
    Peptides, 2003;24:1035
  2. Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist.
    Jois et al.
    J.Biomol.Struct.Dyn., 2006;23:497
  3. Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90).
    Balasubramaniam et al.
    J.Med.Chem., 2001;44:1479
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BVD 10 include:

1 Citations: Showing 1 - 1

  1. Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion.
    Authors: Demorrow Et al.
    Physiol Rep 2011;300:C1078

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