Endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro
. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo
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Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.
Suga et al.
C-natriuretic peptide: An important regulator of cartilage.
Pejchalova et al.
Natriuretic peptide C receptor signalling in the heart and vasculature.
Rose and Giles