Home / Calcium Binding Protein Modulator Antagonists / CALP2

CALP2

2319 4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2319/1
CALP2
1 Image
Description: Cell-permeable calmodulin antagonist
Alternative Names: Calcium-like peptide 2
Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.

Technical Data

M.Wt:
1357.72
Formula:
C68H104N14O13S
Sequence:
VKFGVGFKVMVF
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
261969-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
    Houtman et al.
    J.Immunol., 2001;166:861
  2. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma.
    Ten Broeke et al.
    FASEB J., 2001;15:1831
  3. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages.
    Ten Broeke et al.
    Lab.Invest., 2004;84:29
  4. De novo design of peptides targeted to the EF hands of calmodulin.
    Villain et al.
    J.Biol.Chem., 2000;274:2676

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for CALP2

The citations listed below are publications that use Tocris products. Selected citations for CALP2 include:

4 Citations: Showing 1 - 4

  1. Optogenetic Inhibition of Gαq Protein Signaling Reduces Calcium Oscillation Stochasticity.
    Authors: Hannanta-anan and Chow
    ACS Synth Biol  2018;7:1488
  2. Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.
    Authors: Heo Et al.
    Sci Rep  2015;5:16895
  3. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
    Authors: Fernández-Velasco Et al.
    PLoS One  2011;6:e20863
  4. Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ.
    Authors: Spehr Et al.
    J Neurosci  2009;29:2125

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for CALP2

There are currently no reviews for this product. Be the first to review CALP2 and earn rewards!

Have you used CALP2?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.