Catalog Number: 2319
Alternate Names: Calcium-like peptide 2
Biological Activity
Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.
Technical Data
  • M.Wt:
    1357.72
  • Formula:
    C68H104N14O13S
  • Sequence:
    VKFGVGFKVMVF
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    261969-04-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
    Houtman et al.
    J.Immunol., 2001;166:861
  2. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma.
    Ten Broeke et al.
    FASEB J., 2001;15:1831
  3. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages.
    Ten Broeke et al.
    Lab.Invest., 2004;84:29
  4. De novo design of peptides targeted to the EF hands of calmodulin.
    Villain et al.
    J.Biol.Chem., 2000;274:2676
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CALP2 include:

2 Citations: Showing 1 - 2
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  1. Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.
    Authors: Heo Et al.
    Sci Rep 2015;5:16895
  2. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
    Authors: Fernández-Velasco Et al.
    PLoS One 2011;6:e20863

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