Biological ActivityCALP2 is a cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
Houtman et al.
Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma.
Ten Broeke et al.
FASEB J., 2001;15:1831
Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages.
Ten Broeke et al.
De novo design of peptides targeted to the EF hands of calmodulin.
Villain et al.
Citations for CALP2
The citations listed below are publications that use Tocris products. Selected citations for CALP2 include:
4 Citations: Showing 1 - 4
Optogenetic Inhibition of Gαq Protein Signaling Reduces Calcium Oscillation Stochasticity.
Authors: Hannanta-anan and Chow
ACS Synth Biol 2018;7:1488
Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.
Authors: Heo Et al.
Sci Rep 2015;5:16895
RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
Authors: Fernández-Velasco Et al.
PLoS One 2011;6:e20863
Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ.
Authors: Spehr Et al.
J Neurosci 2009;29:2125
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