Discontinued Product

2319 has been discontinued.
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Description: Cell-permeable calmodulin antagonist
Alternative Names: Calcium-like peptide 2
Product Details
Citations (4)

Biological Activity

CALP2 is a cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.

Technical Data

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
    Houtman et al.
    J.Immunol., 2001;166:861
  2. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma.
    Ten Broeke et al.
    FASEB J., 2001;15:1831
  3. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages.
    Ten Broeke et al.
    Lab.Invest., 2004;84:29
  4. De novo design of peptides targeted to the EF hands of calmodulin.
    Villain et al.
    J.Biol.Chem., 2000;274:2676

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for CALP2

The citations listed below are publications that use Tocris products. Selected citations for CALP2 include:

4 Citations: Showing 1 - 4


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