Cantharidin
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Biological Activity
Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice.
Eldridge and Casida
Toxicol.Appl.Pharmacol., 1995;130:95 -
Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A.
Honkanen
FEBS Lett., 1993;330:283 -
The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability.
Knapp et al.
J.Pharmacol.Exp.Ther., 1999;289:1480
Product Datasheets
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Citations for Cantharidin
The citations listed below are publications that use Tocris products. Selected citations for Cantharidin include:
5 Citations: Showing 1 - 5
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Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Authors: Lang Et al.
Cell Stem Cell 2019;24:93
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
Authors: Shuhaibar Et al.
Elife 2017;6
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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
J Biol Chem 2015;2
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Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Authors: Gray Et al.
Cell Death Dis 2014;289:14600
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Authors: Egbert Et al.
Development 2014;141:3594
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