Catalog Number: 1548
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Biological Activity
Natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.
Technical Data
  • M.Wt:
    196.2
  • Formula:
    C10H12O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    56-25-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice.
    Eldridge and Casida
    Toxicol.Appl.Pharmacol., 1995;130:95
  2. Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A.
    Honkanen
    FEBS Lett., 1993;330:283
  3. The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability.
    Knapp et al.
    J.Pharmacol.Exp.Ther., 1999;289:1480
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cantharidin include:

2 Citations: Showing 1 - 2
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  1. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Biol Chem 2015;2
  2. Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
    Authors: Gray Et al.
    Cell Death Dis 2014;289:14600

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