Biological ActivityCocaine- and amphetamine-regulated transcript (CART) with potent appetite-suppressing activity. Satiety factor; inhibits normal and starvation-induced feeding. Closely related to the actions of leptin and neuropeptide Y; blocks the neuropeptide Y-induced feeding response. Induces anxiety and stress behavior in rodents.
(Modifications: Disulfide bridge between 14 - 32, 20 - 40, 34 - 47)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CART, a new anorectic peptide.
Thim et al.
Int.J.Biochem.Cell Biol., 1998;30:1281
Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.
Ludvigsen et al.
Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents.
Chaki et al.
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