CART (62-76) (rat, human)

Biological Activity

Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding.
   Volkoff and Peter
   Brain Res., 2000;887:125
2. Cocaine and amphetamine-regulated transcript peptide (CART62-76)-induced changes in regional monoamine levels in rat brain.
   Vaarmann and Kask
   Neuropeptides, 2001;35:292
3. Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on release of Ins from isolated rat islets.
   Colombo et al.
   Pancreas, 2003;27:161

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