CART (62-76) (rat, human)
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Description: Neuromodulating neuropeptide fragment; inhibits food intake in vivo
Alternative Names: Cocaine and amphetamine-regulated transcript (62-76) (rat, human)
Biological Activity
Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.Technical Data
M.Wt:
1570.77
Formula:
C64H99N17O23S3
Sequence:
YGQVPMCDAGEQCAV
Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
210978-19-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding.
Volkoff and Peter
Brain Res., 2000;887:125 -
Cocaine and amphetamine-regulated transcript peptide (CART62-76)-induced changes in regional monoamine levels in rat brain.
Vaarmann and Kask
Neuropeptides, 2001;35:292 -
Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on release of Ins from isolated rat islets.
Colombo et al.
Pancreas, 2003;27:161
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