Catalog Number: 2722
Alternate Names: Chromogranin A344-364
Biological Activity
Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
Technical Data
  • M.Wt:
    2425.84
  • Formula:
    C107H173N37O26S
  • Sequence:
    RSMRLSFRARGYGFRGPGLQL
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    142211-96-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity.
    Mahata et al.
    Mol.Endocrinol., 2000;14:1525
  2. Novel autocrine feedback control of catecholamine release.
    Mahata et al.
    J.Clin.Invest., 1997;100:1623
  3. Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides.
    Kruger et al.
    Regul.Peptides, 2003;114:29

Have you used Catestatin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information