Catalog Number: 2722
Alternate Names: Chromogranin A344-364
Biological Activity
Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 2 mg/ml in 10% acetonitrile
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity.
    Mahata et al.
    Mol.Endocrinol., 2000;14:1525
  2. Novel autocrine feedback control of catecholamine release.
    Mahata et al.
    J.Clin.Invest., 1997;100:1623
  3. Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides.
    Kruger et al.
    Regul.Peptides, 2003;114:29
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