Biological ActivityCH 275 is a potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin.
Chen et al.
Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1).
Rivier et al.
The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat.
Vasilaki et al.
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