Catalog Number: 3122
Biological Activity
Non-competitive NMDA receptor antagonist (IC50 = 0.4 μM). Inhibits Ca2+ influx and glutamate-induced toxicity in central nervous system neurons. Exhibits age-dependent physiological effects; induces a sleep-like state in young mice and hyperactivity in older mice.
Technical Data
  • M.Wt:
    2683.8
  • Formula:
    C110H175N31O45S
  • Sequence:
    GEXXYQKMLXNLRXAEVKKNA

    (Modifications: X = Gla, Ala-21 = C-terminal amide)

  • Storage:
    Store at -20°C
  • CAS No:
    127476-26-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. Conantokin-T.
    Haack et al.
    J.Biol.Chem., 1990;265:6025
  2. Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons.
    Klein et al.
    Neuropharmacology, 1999;38:1819
  3. Amino acid determinants for NMDA receptor inhibition by conantokin-T.
    Warder et al.
    J.Neurochem., 2001;77:812

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