CP 80633

Catalog # Availability Size / Price Qty
2729/10
2729/50
CP 80633 | CAS No. 135637-46-6 | Phosphodiesterase Inhibitors
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Description: Selective PDE4 inhibitor

Chemical Name: 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone

Purity: ≥99%

Product Details
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Biological Activity

Selective inhibitor of phosphodiesterase type 4 (IC50 values are 1.9, > 100, > 100, > 100 and > 100 μM for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells. Displays anti-inflammatory and bronchodilatory effects in vivo.

Technical Data

M.Wt:
316.39
Formula:
C18H24N2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
135637-46-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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