Biological ActivityBombesin receptor antagonist; inhibits bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Centrally active in vivo.
(Modifications: X = Glp, Phe-12 = D-Phe, Gly-14 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
[d-Phe12]bombesin analogues: a new class of bombesin receptor antagonists.
Heinz-Erian et al.
(D-Phe12) Bombesin and substance P analogues function as central bombesin receptor antagonists.
Merali et al.
Localization of receptors for bombesin-like peptides in the rat brain.
Moody et al.
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