Catalog Number: 2334
Biological Activity
Endocytosis inhibitor that blocks the interaction of dynamin with amphiphysin 1 and 2. Impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).
Technical Data
  • M.Wt:
    1566.78
  • Formula:
    C69H111N23O19
  • Sequence:
    PPPQVPSRPNRAPPG
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    251939-41-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of AMPA receptor cycling in synaptic transmission and plasticity.
    L?scher et al.
    Neuron, 1999;24:649
  2. Metabolic glutamate receptor activation causes a rapid redistribution of AMPA receptors.
    Xiao et al.
    Neuropharmacology, 2001;41:664
  3. The amphiphysin family of proteins and their role in endocytosis at the synapse.
    Wigge and McMahon
    Trends Neursci., 1998;21:339

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