Endocytosis inhibitor that blocks the interaction of dynamin with amphiphysin 1 and 2. Impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).
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Role of AMPA receptor cycling in synaptic transmission and plasticity.
L?scher et al.
Metabolic glutamate receptor activation causes a rapid redistribution of AMPA receptors.
Xiao et al.
The amphiphysin family of proteins and their role in endocytosis at the synapse.
Wigge and McMahon
Trends Neursci., 1998;21:339