DBZ

  ( 3 citations )    
Product Datasheet
Catalog Number:4489
Alternate Names:Dibenzazepine
Chemical Name:N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Product Details
Citations (3)
Reviews
Biological Activity
Inhibitor of γ-secretase. Blocks Notch cleavage (IC50< 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.
Technical Data
  • M.Wt:
    463.48
  • Formula:
    C26H23F2N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    209984-56-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DBZ include:

3 Citations: Showing 1 - 3
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  1. Stage-specific effects of Notch activation during skeletal myogenesis.
    Authors: Bi Et al.
    Elife  2016;5
  2. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
    Authors: Bi Et al.
    Nat Med  2014;20:911
  3. The role of Notch and γ-secretase inhibition in an ovarian cancer model.
    Authors: Shah Et al.
    J Reprod Dev  2013;33:801

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