Catalog Number: 4489
Alternate Names: Dibenzazepine
Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Biological Activity
Inhibitor of γ-secretase. Blocks Notch cleavage (IC50< 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of Notch and APP.
    Groth et al.
    Mol.Pharmacol., 2010;77:567
  2. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
    van Es et al.
    Nature, 2005;435:959
  3. Notch inhibition allows oncogene-independent generation of iPS cells.
    Ichida et al.
    Nat.Chem.Biol., 2014;10:632

The citations listed below are publications that use Tocris products. Selected citations for DBZ include:

Showing Results 1 - 2 of 2

  1. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
    Authors: Bi Et al.
    Nat Med
  2. The role of Notch and γ-secretase inhibition in an ovarian cancer model.
    Authors: Shah Et al.
    J Reprod Dev
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