Inhibitor of γ
-secretase. Blocks Notch cleavage (IC50
< 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.
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All Tocris products are intended for laboratory research use only.
Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of Notch and APP.
Groth et al.
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
van Es et al.
Notch inhibition allows oncogene-independent generation of iPS cells.
Ichida et al.
The citations listed below are publications that use Tocris products. Selected citations for DBZ include:
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