DBZ

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4489/10
4489/50
DBZ | CAS No. 209984-56-5 | Secretase Inhibitors
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Description: γ-secretase inhibitor; inhibits Notch pathway
Alternative Names: Dibenzazepine

Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

Product Details
Citations (9)
Reviews (1)

Biological Activity

Inhibitor of γ-secretase. Blocks Notch cleavage (IC50< 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.

Technical Data

Formula:
C26H23F2N3O3
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
209984-56-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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DBZ
By Minjin Jeong on 09/09/2019
Species: Mouse

Differentiation of hiPSCs into optic progenitor cells.


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