DBZ

Tocris Bioscience | Catalog # 4489

γ-secretase inhibitor; inhibits Notch pathway
Tocris Bioscience

Key Product Details

Description

γ-secretase inhibitor; inhibits Notch pathway

Alternative Names

Dibenzazepine,YO-01027
View all Secretase Inhibitors »

Product Description

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human naïve-state pluripotency in non-hypoxic conditions.

DBZ synthesized to Ancillary Material Grade also available.

Product Specifications for DBZ

Molecular Weight

463.48

Formula

C26H23F2N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

CAS Number

209984-56-5

PubChem ID

11454028

InChI Key

QSHGISMANBKLQL-OWJWWREXSA-N

SMILES

CN1C2=C(C=CC=C2)C3=C(C=CC=C3)[C@H](NC([C@@H](NC(CC4=CC(F)=CC(F)=C4)=O)C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.35 100

Preparing Stock Solutions for DBZ

The following data is based on the product molecular weight 463.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Product Documents for DBZ

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DBZ

For research use only

Customer Reviews for DBZ (1)

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  • DBZ
    Name: Minjin Jeong
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: iPSCs
    Verified Customer | Posted 09/09/2019
    For obtaining a higher solubility, I recommend warming at 37°C.
    Differentiation of hiPSCs into optic progenitor cells.

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