DEA

Catalog # Availability Size / Price Qty
1485/5
1485/25
DEA | CAS No. 150314-35-5 | Cannabinoid R1/CB1 Agonists
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Description: Endogenous CB1 agonist
Alternative Names: Docosatetraenylethanolamide

Chemical Name: N-(2-Hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide

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Biological Activity

Potent endocannabinoid and anandamide (Cat. No. 1339) analog that activates CB1 receptors in microglia and binds to rat synaptosomal membranes (Ki = 34.4 nM). Cannabimimetic in vivo.

Technical Data

M.Wt:
375.59
Formula:
C24H41NO2
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Desiccate at -20°C
CAS No:
150314-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides.
    Barg et al.
    Eur.J.Pharmacol., 1995;287:145
  2. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor.
    Hanus et al.
    J.Med.Chem., 1993;36:3032
  3. Microglial cells produce endocannabinoids and express functional cannabinoid receptors: evidence that docosatetraenylethanolamide (DEA) is an additional endocannabinoid.
    Walter et al.
    Soc.Neurosci.Abstr., 2001;:634.16

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