2 nAChR partial agonist (IC50
= 105 nM). Exhibits >20-fold selectivity for α
2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo
. Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.
Rollema et al.