DL-AP5 Sodium salt
Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt
Biological ActivitySodium salt of DL-AP5 (Cat. No. 0105). Potent NMDA antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378
Citations for DL-AP5 Sodium salt
The citations listed below are publications that use Tocris products. Selected citations for DL-AP5 Sodium salt include:
7 Citations: Showing 1 - 7
Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
Authors: Zhao Et al.
Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses.
Authors: Maschi and Klyachko
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Authors: Athilingam Et al.
Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
Authors: Pan Et al.
PLoS One 2016;6:28137
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Authors: Cazares Et al.
J Neurosci 2016;36:11208
Fixed single-cell transcriptomic characterization of human radial glial diversity.
Authors: Thomsen Et al.
Sci Rep 2016;13:87
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Purinergic Signal 2015;10:e0131430
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DL-AP5 (40 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
This small molecule was used as NMDA glutamate site antagonist in ex-vivo patch clamp electrophysiology to investigate neuronal excitability.