DL-AP5 Sodium salt
Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt
Biological ActivityDL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.
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The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378
Citations for DL-AP5 Sodium salt
The citations listed below are publications that use Tocris products. Selected citations for DL-AP5 Sodium salt include:
28 Citations: Showing 1 - 10
Interactions between Brainstem Neurons That Regulate the Motility to the Stomach.
Authors: Niaz Et al.
J Neurosci 2022;42:5212-5228
Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Authors: Katarzyna Et al.
EMBO J 2022;41:e110192
Light and electron microscopic imaging of synaptic vesicle endocytosis at mouse hippocampal cultures.
Authors: Bo Et al.
STAR Protoc 2022;3:101495
Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility.
Authors: Stefano Et al.
Front Neurosci 2022;16:961042
Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.
Authors: Seong-Woo Et al.
Front Cell Neurosci 2022;16:889663
Generation of vascularized brain organoids to study neurovascular interactions.
Authors: Jian Et al.
Protocol for detecting plastic changes in defined neuronal populations in neuropathic mice.
Authors: Gerald W Et al.
STAR Protoc 2021;2:100698
Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption.
Authors: Sophie Et al.
Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons.
Authors: Stephan A Et al.
Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.
Authors: Richard A Et al.
Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN.
Authors: Yalun Et al.
Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility.
Authors: Marla B Et al.
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
Authors: Raul Et al.
Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.
Authors: Xinhuai Et al.
Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
Authors: Pati Et al.
Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior.
Authors: Hyunjung Et al.
Biol Psychiatry 2020;88:797-808
Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development.
Authors: Genevieve Et al.
Cell Rep 2020;30:3051-3066.e7
Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers.
Authors: Meng-Jung Et al.
Front Neurosci 2020;14:563964
Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder.
Authors: Mauro Et al.
Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses.
Authors: Darío Et al.
Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
Authors: Zhao Et al.
Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses.
Authors: Maschi and Klyachko
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Authors: Athilingam Et al.
Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
Authors: Pan Et al.
PLoS One 2016;6:28137
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Authors: Cazares Et al.
J Neurosci 2016;36:11208
Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
Authors: Allan E Et al.
Fixed single-cell transcriptomic characterization of human radial glial diversity.
Authors: Thomsen Et al.
Sci Rep 2016;13:87
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Purinergic Signal 2015;10:e0131430
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