DL-AP5 Sodium salt

Tocris Bioscience | Catalog # 3693

Potent and selective NMDA antagonist; sodium salt of DL-AP5
Tocris Bioscience

Key Product Details

Description

Potent and selective NMDA antagonist; sodium salt of DL-AP5
View all NMDA Receptor Antagonists »

Product Description

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

DL mixture, D-isomer and L-isomer also available.

Product Specifications for DL-AP5 Sodium salt

Molecular Weight

219.11

Formula

C5H11NNaO5P

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

DL-2-Amino-5-phosphonopentanoic acid sodium salt

CAS Number

1303993-72-7

PubChem ID

52974251

InChI Key

KWRCYAPNGUCHOE-UHFFFAOYSA-M

SMILES

[Na+].NC(CCCP(O)([O-])=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.91 100

Preparing Stock Solutions for DL-AP5 Sodium salt

The following data is based on the product molecular weight 219.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.56 mL 22.82 mL 45.64 mL
5 mM 0.91 mL 4.56 mL 9.13 mL
10 mM 0.46 mL 2.28 mL 4.56 mL
50 mM 0.09 mL 0.46 mL 0.91 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

Product Documents for DL-AP5 Sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DL-AP5 Sodium salt

For research use only

Citations for DL-AP5 Sodium salt

Customer Reviews for DL-AP5 Sodium salt (2)

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  • Works as expected.
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Paraventricular nucleus of hypothalamus
    Verified Customer | Posted 06/01/2020
    DL-AP5 (40 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
  • NMDA glutamate site antagonist
    Name: Syed Ali
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/04/2018
    This small molecule was used as NMDA glutamate site antagonist in ex-vivo patch clamp electrophysiology to investigate neuronal excitability.

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