DL-AP5 Sodium salt
Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt
Biological ActivitySodium salt of DL-AP5 (Cat. No. 0105). Potent NMDA antagonist.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378
Citations for DL-AP5 Sodium salt
The citations listed below are publications that use Tocris products. Selected citations for DL-AP5 Sodium salt include:
8 Citations: Showing 1 - 8
Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
Authors: Pati Et al.
Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
Authors: Zhao Et al.
Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses.
Authors: Maschi and Klyachko
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Authors: Athilingam Et al.
Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
Authors: Pan Et al.
PLoS One 2016;6:28137
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Authors: Cazares Et al.
J Neurosci 2016;36:11208
Fixed single-cell transcriptomic characterization of human radial glial diversity.
Authors: Thomsen Et al.
Sci Rep 2016;13:87
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Purinergic Signal 2015;10:e0131430
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DL-AP5 (40 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
This small molecule was used as NMDA glutamate site antagonist in ex-vivo patch clamp electrophysiology to investigate neuronal excitability.