DL-AP5 Sodium salt

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DL-AP5 Sodium salt | CAS No. 1303993-72-7 | NMDA Receptor Antagonists
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Description: Potent and selective NMDA antagonist; sodium salt of DL-AP5

Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt

Purity: ≥98%

Product Details
Citations (28)
Supplemental Products

Biological Activity

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

DL mixture, D-isomer and L-isomer also available.

Technical Data

Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for DL-AP5 Sodium salt

The citations listed below are publications that use Tocris products. Selected citations for DL-AP5 Sodium salt include:

28 Citations: Showing 1 - 10

  1. Interactions between Brainstem Neurons That Regulate the Motility to the Stomach.
    Authors: Niaz Et al.
    J Neurosci  2022;42:5212-5228
  2. Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
    Authors: Katarzyna Et al.
    EMBO J  2022;41:e110192
  3. Light and electron microscopic imaging of synaptic vesicle endocytosis at mouse hippocampal cultures.
    Authors: Bo Et al.
    STAR Protoc  2022;3:101495
  4. Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility.
    Authors: Stefano Et al.
    Front Neurosci  2022;16:961042
  5. Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.
    Authors: Seong-Woo Et al.
    Front Cell Neurosci  2022;16:889663
  6. Generation of vascularized brain organoids to study neurovascular interactions.
    Authors: Jian Et al.
    Elife  2022;11
  7. Protocol for detecting plastic changes in defined neuronal populations in neuropathic mice.
    Authors: Gerald W Et al.
    STAR Protoc  2021;2:100698
  8. Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption.
    Authors: Sophie Et al.
    iScience  2021;24:103122
  9. Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons.
    Authors: Stephan A Et al.
    Traffic  2021;22:454-470
  10. Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.
    Authors: Richard A Et al.
    Neuron  2021;109:938-946.e5
  11. Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN.
    Authors: Yalun Et al.
    Elife  2021;10
  12. Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility.
    Authors: Marla B Et al.
    Elife  2021;10
  13. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
    Authors: Raul Et al.
    Elife  2021;10
  14. Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.
    Authors: Xinhuai Et al.
    Elife  2021;10
  15. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
    Authors: Pati Et al.
    ELife  2020;9
  16. Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior.
    Authors: Hyunjung Et al.
    Biol Psychiatry  2020;88:797-808
  17. Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development.
    Authors: Genevieve Et al.
    Cell Rep  2020;30:3051-3066.e7
  18. Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers.
    Authors: Meng-Jung Et al.
    Front Neurosci  2020;14:563964
  19. Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder.
    Authors: Mauro Et al.
    Neuron  2019;101:246-259.e6
  20. Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses.
    Authors: Darío Et al.
    Elife  2018;7
  21. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
    Authors: Zhao Et al.
    iScience  2018;6:138
  22. Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses.
    Authors: Maschi and Klyachko
    Neuron  2017;94:65
  23. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
    Authors: Athilingam Et al.
    Elife  2017;6
  24. Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
    Authors: Pan Et al.
    PLoS One  2016;6:28137
  25. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
    Authors: Cazares Et al.
    J Neurosci  2016;36:11208
  26. Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
    Authors: Allan E Et al.
    Endocrinology  2016;157:3621-30
  27. Fixed single-cell transcriptomic characterization of human radial glial diversity.
    Authors: Thomsen Et al.
    Sci Rep  2016;13:87
  28. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Purinergic Signal  2015;10:e0131430


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