Donepezil hydrochloride

Catalog # Availability Size / Price Qty
Donepezil hydrochloride | CAS No. 120011-70-3 | Cholinesterase Inhibitors
1 Image
Description: Potent AChE inhibitor
Alternative Names: E 2020

Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

Purity: ≥99%

Product Details
Citations (2)

Biological Activity

Donepezil hydrochloride is a potent and selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). In animal models of Alzheimer's disease, Donepezil reduces brain tissue Aβ protein and plaque deposition, restores normal glucose metabolism, reduces neuroinflammation and rescues cognitive dysfunction and memory deficits. The pro-cognitive effects are potentiated by combination with Mefloquine (Cat. No. 6819). In vitro Donepezil reduces LPS-induced inflammation and protects against mitochondrial membrane potential damage.

Technical Data

Soluble to 50 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Donepezil hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:

2 Citations: Showing 1 - 2

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  2. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
    Authors: Morris Et al.
    Ann Clin Transl Neurol  2015;2:1012


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Donepezil hydrochloride

There are currently no reviews for this product. Be the first to review Donepezil hydrochloride and earn rewards!

Have you used Donepezil hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.