Donepezil hydrochloride

Catalog # Availability Size / Price Qty
Donepezil hydrochloride | CAS No. 120011-70-3 | Cholinesterase Inhibitors
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Description: Potent AChE inhibitor
Alternative Names: E 2020

Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

Purity: ≥99%

Product Details
Citations (2)

Biological Activity

Donepezil hydrochloride is a potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.

Deuterated analog also available.

Technical Data

Soluble to 50 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Donepezil hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:

2 Citations: Showing 1 - 2

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  2. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
    Authors: Morris Et al.
    Ann Clin Transl Neurol  2015;2:1012


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