Donepezil hydrochloride

Key Product Details

Product Description

Donepezil hydrochloride is a potent and selective acetylcholinesterase inhibitor (IC₅₀ = 5.7 nM). In animal models of Alzheimer's disease, Donepezil reduces brain tissue Aβ protein and plaque deposition, restores normal glucose metabolism, reduces neuroinflammation and rescues cognitive dysfunction and memory deficits. The pro-cognitive effects are potentiated by combination with Mefloquine (Cat. No. 6819). In vitro Donepezil reduces LPS-induced inflammation and protects against mitochondrial membrane potential damage.

Product Specifications for Donepezil hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Donepezil hydrochloride

The following data is based on the product molecular weight 415.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.81 mL	24.04 mL	48.08 mL
2.5 mM	0.96 mL	4.81 mL	9.62 mL
5 mM	0.48 mL	2.40 mL	4.81 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Hugon Impact of donepezil on brain glucose metabolism assessed using [¹⁸F]2-fluoro-2-deoxy-D-glucose positron emission tomography imaging in a mouse model of Alzheimer's disease induced by intracerebroventricular injection of amyloid-beta peptide. Front.Neurosci. 2022 PMID: 35281502
• Kim Donepezil regulates LPS and Aβ-stimulated neuroinflammation through MAPK/NLRP3 inflammasome/STAT3 signaling. Int.J.Mol.Sci. 2021 PMID: 34638977
• Droguerre Efficacy of THN201, a combination of donepezil and mefloquine, to reverse neurocognitive deficits in Alzheimer's disease. Front.Neurosci. 2020 PMID: 32612499
• Romberg Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept). J.Neurosci. 2011 PMID: 21368062
• Sugimoto Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 2000 PMID: 10637367
• Kryger Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 1999 PMID: 10368299
• Sugimoto Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 1995 PMID: 7490731

Product Documents for Donepezil hydrochloride