Catalog Number: 4385
Alternate Names: E 2020
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
Biological Activity
Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.
Technical Data
  • M.Wt:
    415.95
  • Formula:
    C24H29NO3.HCl
  • Solubility:
    Soluble to 75 mM in water and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    120011-70-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
    Sugimoto et al.
    J.Med.Chem., 1995;38:4821
  2. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
    Kryger et al.
    Structure, 1999;7:297
  3. Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
    Sugimoto et al.
    Curr.Med.Chem., 2000;7:303
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:

1 Citations: Showing 1 - 1

  1. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
    Authors: Morris Et al.
    Ann Clin Transl Neurol 2015;2:1012
Tocris Small Molecules
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Donepezil - d5 hydrochloride

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