Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
Biological ActivityPotent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active.
Deuterated analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Sugimoto et al.
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Kryger et al.
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
Sugimoto et al.
Citations for Donepezil hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:
2 Citations: Showing 1 - 2
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
Authors: Morris Et al.
Ann Clin Transl Neurol 2015;2:1012
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