Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
Biological ActivityDonepezil hydrochloride is a potent and selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). In animal models of Alzheimer's disease, Donepezil reduces brain tissue Aβ protein and plaque deposition, restores normal glucose metabolism, reduces neuroinflammation and rescues cognitive dysfunction and memory deficits. The pro-cognitive effects are potentiated by combination with Mefloquine (Cat. No. 6819). In vitro Donepezil reduces LPS-induced inflammation and protects against mitochondrial membrane potential damage.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Sugimoto et al.
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Kryger et al.
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
Sugimoto et al.
Citations for Donepezil hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Donepezil hydrochloride include:
2 Citations: Showing 1 - 2
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
Authors: Morris Et al.
Ann Clin Transl Neurol 2015;2:1012
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