Catalog Number: 3665
Chemical Name: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazine hydrochloride
Biological Activity
Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief.
    Letienne et al.
    J.Pharmacol.Exp.Ther., 2003;305:749
  2. Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action?
    Letienne et al.
    J.Pharmacol.Exp.Ther., 2005;315:849
  3. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors.
    Munoz-Islas et al.
    Br.J.Pharmacol., 2006;149:82

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