EG 00229

  ( 1 citations )    
Product Datasheet
Catalog Number:4931
Chemical Name:N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine
Product Details
Citations (1)
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Reviews
Biological Activity
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.
Technical Data
  • M.Wt:
    497.57
  • Formula:
    C17H19N7O5S3
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1018927-63-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for EG 00229 include:

1 Citations: Showing 1 - 1

  1. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway.
    Authors: Nissen Et al.
    J.Neurochem.  2013;127:394

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