Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50
= 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1
Soluble to 20 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.
Williams et al.
Cell Rep., 2015;11:43