Catalog Number: 0971
Chemical Name: (2S)-α-Ethylglutamic acid
Biological Activity
Selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Also available as part of the Group II mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    175.18
  • Formula:
    C7H13NO4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    170984-72-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Potent antagonists at the L-AP4- and (1S, 3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.
    Jane et al.
    Neuropharmacology, 1996;35:1029
Citations:

The citations listed below are publications that use Tocris products. Selected citations for EGLU include:

4 Citations: Showing 1 - 4
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    J Neurosci 2011;108:9993
  3. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
    Authors: Kaushal and Schlichter
    Proc Natl Acad Sci U S A 2008;28:2221
  4. Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.
    Authors: Smith and Otis
    Proc Natl Acad Sci U S A 2005;102:14901

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