Biological ActivityHigh affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
(Modifications: Disulfide bridge: 6-11)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling.
Deng et al.
Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension.
Yang et al.
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