Biological ActivityHigh affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
(Modifications: Disulfide bridge: 6-11)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling.
Deng et al.
Elabela/Toddler Is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension.
Yang et al.
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
Reviews for ELA-21 (human)
There are currently no reviews for this product. Be the first to review ELA-21 (human) and earn rewards!
Have you used ELA-21 (human)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image