Exo1

Catalog # Availability Size / Price Qty
1850/10
1850/50
Translocation, Exo/Endocytosis Products Small Molecule
1 Image
Description: Inhibits Golgi-ER traffic; blocks exocytosis

Chemical Name: 2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).

Technical Data

M.Wt:
273.26
Formula:
C15H12FNO3
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
461681-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Exo1: A new chemical inhibitor of the exocytic pathway.
    Feng et al.
    Proc.Natl.Acad.Sci.U.S.A., 2003;100:6469

Product Datasheets

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Citations for Exo1

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2 Citations: Showing 1 - 2

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