Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50
~ 20 mM). Has similar, but not identical, action to brefeldin A
(Cat. No. 1231).
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All Tocris products are intended for laboratory research use only.
Exo1: A new chemical inhibitor of the exocytic pathway.
Feng et al.