Catalog Number: 1850
Chemical Name: 2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester
Biological Activity
Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).
Technical Data
  • M.Wt:
    273.26
  • Formula:
    C15H12FNO3
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    461681-88-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Exo1: A new chemical inhibitor of the exocytic pathway.
    Feng et al.
    Proc.Natl.Acad.Sci.U.S.A., 2003;100:6469
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Exo1 include:

1 Citations: Showing 1 - 1

  1. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits.
    Authors: Greene Et al.
    J.Pharmacol.Exp.Ther. 2017;362:177

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