Selective and irreversible δ
-opioid agonist (EC50
= 8 nM); acts by alkylating the receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site.
Rothman et al.
μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate.
Schoffelmeer et al.
Irreversible ligands with high selectivity toward δ or μ opiate receptors.
Rice et al.