Endogenous melanocortin MC3
receptor agonist (pKi
= 7.46) that displays ~ 40-fold selectivity over MC4
. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo
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Melanocortins and cardiovascular regulation.
Versteeg et al.
Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain.
Lindblom et al.
Brain Res., 1998;810:161
Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats.
Jansone et al.