Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion. However it induces insulin expression in intestinal epithelial cells, which can restore glucose homeostasis when implanted into diabetic mice.
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Exon duplication and divergence in the human preproglucagon gene.
Bell et al.
Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake.
Navarro et al.
Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells.
Suzuki et al.
The citations listed below are publications that use Tocris products. Selected citations for Glucagon-like peptide 1 (1-37) (human, rat) include:
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