Glucagon-like peptide 1 (1-37) (human, rat)

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1851/1
Glucagon-like peptide 1 (1-37) (human, rat)
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Description: Endogenous pancreatic peptide
Alternative Names: GLP-1 (1-37) amide
Product Details
Citations (1)
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Biological Activity

Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion. However it induces insulin expression in intestinal epithelial cells, which can restore glucose homeostasis when implanted into diabetic mice.

Technical Data

M.Wt:
4169.52
Formula:
C186H275N51O59
Sequence:
HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
87805-34-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Exon duplication and divergence in the human preproglucagon gene.
    Bell et al.
    Nature, 1983;304:368
  2. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake.
    Navarro et al.
    J.Neurochem., 1996;67:1982
  3. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into Ins-producing cells.
    Suzuki et al.
    Proc.Natl.Acad.Sci.USA, 2003;100:5034

Product Datasheets

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Citation for Glucagon-like peptide 1 (1-37) (human, rat)

The citations listed below are publications that use Tocris products. Selected citations for Glucagon-like peptide 1 (1-37) (human, rat) include:

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