Catalog Number: 1109
Chemical Name: 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide
Biological Activity
A potent and selective dopamine D3 receptor antagonist, with a Ki value of 0.3 nM� and > 100- fold selectivity over D2 and D4 sites.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194.
    Audinot et al.
    J.Pharmacol.Exp.Ther., 1998;287:187
  2. Dopamine D3 receptors are not involved in the induction of c-fos mRNA by neuroleptic drugs: comparison of the dopamine D3 receptor antagonist GR 103691 with the typical and atypical neuroleptics.
    Hurley et al.
    Eur.J.Pharmacol., 1996;318:283
  3. A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor.
    Murray et al.
    Bioorg.Med.Chem.Lett., 1995;5:219
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