Potent neuropeptide Y (NPY) Y1
receptor antagonist (pA2
= 10 and 10.5 at rY1
, receptors respectively). Also a potent and selective NPY Y4
receptor agonist (pEC50
values are 6.0, 8.6 and 6.1 for rY2
receptors respectively). Suppresses food intake in rats in vivo
. Also has affinity for neuropeptide FF (NPFF) receptors in vitro
= 43-73 nM).
(Modifications: X = Dpr, Amide Bridge = 2 - 4*, 4 - 2*, Tyr-9 = C-terminal amide)
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats.
Ishihara et al.
GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists.
Parker et al.
Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226.
Mollereau et al.