Catalog Number: 1670
Biological Activity
Tachykinin NK1 receptor antagonist.
Technical Data
  • M.Wt:
    1386.57
  • Formula:
    C69H91N15O16
  • Sequence:
    XADPNKFYPLW

    (Modifications: X-1 = Glp, Leu-10 = spiro-g-lactam-Leu, Trp-11 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    129623-01-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat.
    Guo et al.
    Eur.J.Pharmacol., 1995;281:49
  2. Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions.
    Lecci et al.
    Life Sci., 1992;51:PL277
  3. A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase-resistant, selective neurokinin NK-1 receptor antagonist.
    Hagan et al.
    Br.J.Pharmacol., 1991;102:168P

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