GR 82334

Catalog # Availability Size / Price Qty
1670/1
GR 82334
1 Image
Description: NK1 antagonist
Product Details
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Biological Activity

Tachykinin NK1 receptor antagonist.

Technical Data

M.Wt:
1386.57
Formula:
C69H91N15O16
Sequence:
XADPNKFYPLW

(Modifications: X-1 = Glp, Leu-10 = spiro-g-lactam-Leu, Trp-11 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
129623-01-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat.
    Guo et al.
    Eur.J.Pharmacol., 1995;281:49
  2. Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions.
    Lecci et al.
    Life Sci., 1992;51:PL277
  3. A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase-resistant, selective neurokinin NK-1 receptor antagonist.
    Hagan et al.
    Br.J.Pharmacol., 1991;102:168P

Product Datasheets

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