Biological ActivityGR 82334 is a tachykinin NK1 receptor antagonist.
(Modifications: X-1 = Glp, Leu-10 = spiro-g-lactam-Leu, Trp-11 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat.
Guo et al.
Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions.
Lecci et al.
Life Sci., 1992;51:PL277
A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase-resistant, selective neurokinin NK-1 receptor antagonist.
Hagan et al.
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