Catalog Number: 1667
Biological Activity
Potent and selective tachykinin NK2 receptor antagonist (pKB values are 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors respectively). Active in vivo.
Technical Data
  • M.Wt:
    904.08
  • Formula:
    C49H61N9O8
  • Sequence:
    AAWFPPX

    (Modifications: Ala-1 = N-(Bz)Ala, Trp-3 = D-Trp, Pro-5 = D-Pro, X = Nle with C-terminal amide)

  • Solubility:
    Soluble to 4 mg/ml in ethanol
  • Storage:
    Desiccate at -20°C
  • CAS No:
    141636-65-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. An investigation of tachykinin NK2 receptor subtypes in the rat.
    Matuszek et al.
    Eur.J.Pharmacol., 1998;352:103
  2. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor.
    McElroy et al.
    J.Med.Chem., 1992;35:2582
  3. Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum.
    Zagorodnyuk et al.
    Br.J.Pharmacol., 1995;115:237

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