Catalog Number: 0396
Chemical Name: N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride
Biological Activity
Protein kinase inhibitor. Inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
    Hidaka et al.
    Biochemistry, 1984;23:5036
  2. Pharmacology of protein kinase inhibitors.
    Hidaka and Koybashi
    Annu.Rev.Pharmacol.Toxicol., 1992;32:377
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