Human CRHR1 PE-conjugated Antibody

FAB3930P has been discontinued. View all CRHR1 products.
    
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  • Species Reactivity
    Human
  • Specificity
    Detects human CRHR‑1 transfectants but not irrelevant transfectants.
  • Source
    Monoclonal Mouse IgG2A Clone # 343919
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    NS0 mouse myeloma cell line transfected with human CRHR-1
    Ser24-Val415
    Accession # NP_004373
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of CRHR1 in BaF3 Mouse Cell Line Transfected with Human CRHR1 by Flow Cytometry. BaF3 mouse pro-B cell line transfected with human CRHR1 was stained with Mouse Anti-Human CRHR1 PE‑conjugated Monoclonal Antibody (Catalog # FAB3930P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CRHR1

Corticotrophin-Releasing Hormone Receptor 1 (CRHR1), also known as CRFR-1, is a 65-70 kDa, 7TM protein that belongs to the G protein-coupled receptor family 2. CRHR1 is expressed in multiple regions of the brain, where neurons in the cortex, amygdala, hippocampus and olfactory bulb all express CRHR1. Cells that express CRHR1 outside the CNS include adrenal fasciculata cells, neutrophils, adipocytes, pituitary corticotrophs, macrophages, testicular Leydig cells, and endometrial stromal cells. Functionally, the CRHR1 receptor mediates ACTH and beta -Endorphin release from the pituitary, VEGF secretion by mast cells, and BDNF expression by cerebellum neurons. The immunogen for this antibody corresponds to one of at least eight alternately spliced forms and shows a 29 amino acid deletion in the first cytoplasmic domain relative to the full-length isoform. Human CRHR1 shares 97% amino acid sequence identity with mouse and rat CRHR1.

  • Long Name:
    Corticotropin Releasing Hormone Receptor 1
  • Entrez Gene IDs:
    1394 (Human); 12921 (Mouse)
  • Alternate Names:
    CHR-R1; corticotropin releasing hormone receptor 1; corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF1; CRFR; CRF-R; CRFR1; CRF-R1; CRF-R-1; CRFR-1; CRHR1; CRH-R-1; CRHR1f; CRH-R1h; CRHR1L; CRHRCRH-R1; seven transmembrane helix receptor
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