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Human IFN-gamma Luminex Performance Assay

Catalog #: LUH285 Datasheet / COA / SDS

Discontinued Product

LUH285 has been discontinued and is replaced by LUHM285.

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Human IFN-gamma Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

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Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IFN-gamma

IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.

Long Name
Interferon gamma
Entrez Gene IDs
3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
Alternate Names
IFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma

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Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IFN-gamma Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

34 Citations: Showing 1 - 10
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  1. Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery.
    Authors: Stoppelkamp S, Veseli K, Stang K, Schlensak C, Wendel H, Walker T
    PLoS ONE, 2015-08-11;10(8):e0135527.
    Species: Human
    Sample Types: Plasma
  2. Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue.
    Authors: Beck I, Van Crombruggen K, Holtappels G, Daubeuf F, Frossard N, Bachert C, De Bosscher K
    PLoS ONE, 2015-04-13;10(4):e0123068.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings.
    Authors: Tenforde M, Gupte N, Dowdy D, Asmuth D, Balagopal A, Pollard R, Sugandhavesa P, Lama J, Pillay S, Cardoso S, Pawar J, Santos B, Riviere C, Mwelase N, Kanyama C, Kumwenda J, Hakim J, Kumarasamy N, Bollinger R, Semba R, Campbell T, Gupta A
    PLoS ONE, 2015-02-26;10(2):e0117424.
    Species: Human
    Sample Types: Plasma
  4. Sputum IgE and cytokines in asthma: relationship with sputum cellular profile.
    Authors: Manise M, Holtappels G, Van Crombruggen K, Schleich F, Bachert C, Louis R
    PLoS ONE, 2013-03-26;8(0):U111.
    Species: Human
    Sample Types: Sputum
  5. Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype.
    Authors: Belmonte L, Beutheu Youmba S, Bertiaux-Vandaele N, Antonietti M, Lecleire S, Zalar A, Gourcerol G, Leroi A, Dechelotte P, Coeffier M, Ducrotte P
    PLoS ONE, 2012-08-17;7(8):e42777.
    Species: Human
    Sample Types: Tissue Homogenates
  6. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
    Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
    PLoS ONE, 2012-02-16;7(2):e32218.
    Species: Human
    Sample Types: Serum
  7. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011-07-21;179(3):1157-70.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections.
    Authors: Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S
    PLoS ONE, 2011-06-08;6(6):e20541.
    Species: Human
    Sample Types: Serum
  9. Effect of Lactobacillus paracasei ST11 on a nasal provocation test with grass pollen in allergic rhinitis.
    Authors: Wassenberg J, Nutten S, Audran R, Barbier N, Aubert V, Moulin J, Mercenier A, Spertini F
    Clin. Exp. Allergy, 2011-04-01;41(4):565-73.
    Species: Human
    Sample Types: Nasal Fluid
  10. Probiotic Lactobacillus casei Shirota supplementation does not modulate immunity in healthy men with reduced natural killer cell activity.
    Authors: Seifert S, Bub A, Franz CM, Watzl B
    J. Nutr., 2011-03-23;141(5):978-84.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia.
    Authors: Durig J, Duhrsen U, Klein-Hitpass L, Worm J, Hansen JB, Orum H, Wissenbach M
    Leukemia, 2011-03-01;25(4):638-47.
    Species: Human
    Sample Types: Serum
  12. The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans.
    Authors: Di Meglio P, Di Cesare A, Laggner U
    PLoS ONE, 2011-02-22;6(2):e17160.
    Species: Human
    Sample Types: Cell Culture Supernates
  13. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.
    Authors: Buglio D, Khaskhely NM, Voo KS, Martinez-Valdez H, Liu YJ, Younes A
    Blood, 2011-01-14;117(10):2910-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  14. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.
    Authors: Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C
    Eur. J. Immunol., 2010-09-01;40(9):2450-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  15. Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication.
    Authors: Damas JK, Landro L, Fevang B, Heggelund L, Tjonnfjord GE, Floisand Y, Halvorsen B, Froland SS, Aukrust P
    Clin. Exp. Immunol., 2009-09-01;157(3):400-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. Clinical efficacy and immune regulation with peanut oral immunotherapy.
    Authors: Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW
    J. Allergy Clin. Immunol., 2009-07-03;124(2):292-300, 300..
    Species: Human
    Sample Types: Cell Culture Supernates
  17. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
    Authors: Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
    J. Immunol., 2009-05-15;182(10):6460-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  18. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
    Authors: O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE
    Proc. Natl. Acad. Sci. U.S.A., 2009-03-30;106(15):6099-104.
    Species: Human
    Sample Types: Cell Culture Supernates
  19. Cigarette smoke facilitates allergen penetration across respiratory epithelium.
    Authors: Gangl K, Reininger R, Bernhard D, Campana R, Pree I, Reisinger J, Kneidinger M, Kundi M, Dolznig H, Thurnher D, Valent P, Chen KW, Vrtala S, Spitzauer S, Valenta R, Niederberger V
    Allergy, 2008-12-16;64(3):398-405.
    Species: Human
    Sample Types: Cell Culture Supernates
  20. NF-kappaB modulates sensitivity to apoptosis, proinflammatory and migratory potential in short- versus long-term cultured human gammadelta lymphocytes.
    Authors: Ferrarini M, Delfanti F, Gianolini M, Rizzi C, Alfano M, Lazzarin A, Biswas P
    J. Immunol., 2008-11-01;181(9):5857-64.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. An evaluation of commercial fluorescent bead-based luminex cytokine assays.
    Authors: Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G
    PLoS ONE, 2008-07-02;3(7):e2535.
    Species: Human
    Sample Types: Serum
  22. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.
    Authors: Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH, Scott McIvor R, Wagner JE, Blazar BR, Zhou X
    Mol. Ther., 2008-01-29;16(3):580-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.
    Authors: Mittermann I, Reininger R, Zimmermann M, Gangl K, Reisinger J, Aichberger KJ, Greisenegger EK, Niederberger V, Seipelt J, Bohle B, Kopp T, Akdis CA, Spitzauer S, Valent P, Valenta R
    J. Invest. Dermatol., 2007-12-13;128(6):1451-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  24. Defining cancer cachexia in head and neck squamous cell carcinoma.
    Authors: Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart PW, Weissler MC, Shores CG
    Clin. Cancer Res., 2007-11-15;13(22):6561-7.
    Species: Human
    Sample Types: Serum
  25. Potent induction of TNF-alpha during interaction of immune effectors with oral tumors as a potential mechanism for the loss of NK cell viability and function.
    Authors: Romero-Reyes M, Head C, Cacalano NA, Jewett A
    Apoptosis, 2007-11-01;12(11):2063-75.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage.
    Authors: Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Luo X, Chegini N
    Fertil. Steril., 2007-08-13;89(6):1795-802.
    Species: Human
    Sample Types: Serum
  27. Increased frequency of CD4+ cells expressing CD161 in cancer patients.
    Authors: Iliopoulou EG, Karamouzis MV, Missitzis I, Ardavanis A, Sotiriadou NN, Baxevanis CN, Rigatos G, Papamichail M, Perez SA
    Clin. Cancer Res., 2006-12-01;12(23):6901-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  28. A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55.
    Authors: Ullenhag GJ, Spendlove I, Watson NF, Indar AA, Dube M, Robins RA, Maxwell-Armstrong C, Scholefield JH, Durrant LG
    Clin. Cancer Res., 2006-11-22;12(24):7389-96.
    Species: Human
    Sample Types: Cell Culture Supernates
  29. Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers.
    Authors: Alexis NE, Lay JC, Zeman K, Bennett WE, Peden DB, Soukup JM, Devlin RB, Becker S
    J. Allergy Clin. Immunol., 2006-04-27;117(6):1396-403.
    Species: Human
    Sample Types: Saliva
  30. Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells.
    Authors: Jewett A, Cacalano NA, Head C, Teruel A
    Clin. Cancer Res., 2006-04-01;12(7):1994-2003.
    Species: Human
    Sample Types: Cell Culture Supernates
  31. Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity.
    Authors: Tomic J, White D, Shi Y, Mena J, Hammond C, He L, Miller RL, Spaner DE
    J. Immunol., 2006-03-15;176(6):3830-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  32. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2.
    Authors: Razonable RR, Henault M, Lee LN, Laethem C, Johnston PA, Watson HL, Paya CV
    Antimicrob. Agents Chemother., 2005-04-01;49(4):1617-21.
    Species: Human
    Sample Types: Cell Culture Supernates
  33. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.
    Authors: Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W
    J. Immunol., 2004-10-01;173(7):4433-42.
    Species: Human
    Sample Types: Cell Culture Supernates
  34. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers.
    Authors: Khan SS, Smith MS, Reda D, Suffredini AF, McCoy JP
    Cytometry B Clin Cytom, 2004-09-01;61(1):35-9.
    Species: Human
    Sample Types: Serum

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