|Detection of ILT7/CD85g in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human ILT7/CD85g Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB6287F) and Anti-Human DLEC APC-conjugated Antibody. Quadrant markers were set based on control antibody staining (Catalog # IC003F). View our protocol for Staining Membrane-associated Proteins.|
ILT7, also known as LILRA4 and CD85g, is a 499 amino acid (aa) type I transmembrane glycoprotein that contains four Ig-like domains in its extracellular region. ILT7 is selectively expressed on plasmacytoid dendritic cells (pDC). It binds to BST2/CD317 on bone marrow stromal cells and associates with the gamma subunit of Fc epsilon RI. This receptor complex transmits signals that inhibit the TLR-induced production of type I interferon. The ILT7-mediated interactions between pDC and tumor cells similarly inhibit the production of proinflammatory cytokines and contribute to reduced anti-tumor immune responses. Alternate splicing of human ILT7 generates an isoform that lacks the N-terminal 43 aa of the extracellular domain.
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