Human LAIR1 Fluorescein-conjugated Antibody

  • Species Reactivity
  • Specificity
    Detects human LAIR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human LAIR2 or recombinant mouse LAIR1 is observed.
  • Source
    Monoclonal Mouse IgG2B Clone # 342219
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human LAIR1 isoform 1
    Accession # Q6GTX8
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of LAIR1 in Human Lymphocytes by Flow Cytometry. Human lymphocytes were stained with Mouse Anti-Human LAIR1 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB2664F, filled histogram) or isotype control antibody (Catalog # IC0041F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: LAIR1
LAIR1 (Leukocyte-associated Ig Like Receptor 1) is an inhibitory receptor belonging to the Ig superfamily. It is a 40 kDa type I transmembrane glycoprotein with one extracellular C2-type Ig-like domain and two cytoplasmic ITIMs. Four LAIR1 splice variants exist. LAIR1b has a 17 aa deletion outside the Ig loop in the extracellular domain. It differs from LAIR1c by one aa residue. LAIR1d has a 77 aa truncation in the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells and most thymocytes. Consistent with the presence of ITIM motifs,  LAIR1 inhibits IL-2 and IFN-gamma production by CD4+ T cells, and reduces IgG and IgE production by B cells. LAIR1 is known to bind to collagens -I, -II, -III, and XVII. The extracellular domain of human LAIR1 shares 40% aa identity with that of the mouse protein.
  • Long Name:
    Leukocyte-associated Ig-like Receptor 1
  • Entrez Gene IDs:
    3903 (Human)
  • Alternate Names:
    CD305 antigen; CD305; CD305leukocyte-associated Ig-like receptor 1; hLAIR1; LAIR-1; leukocyte-associated immunoglobulin-like receptor 1
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG2B Fluorescein‑conjugated Control Antibody

Ctrl IC0041F 6  
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Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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