Detection of LAIR1 in Human Lymphocytes by Flow Cytometry.
Human lymphocytes were stained with Mouse Anti-Human LAIR1 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB2664F, filled histogram) or isotype control antibody (Catalog # IC0041F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
LAIR1 (Leukocyte-associated Ig Like Receptor 1) is an inhibitory receptor belonging to the Ig superfamily. It is
a 40 kDa type I transmembrane glycoprotein with one extracellular C2-type Ig-like domain
and two cytoplasmic ITIMs. Four LAIR1 splice variants exist. LAIR1b has
a 17 aa deletion outside the Ig loop in the extracellular domain. It
differs from LAIR1c by one aa residue. LAIR1d has a 77 aa truncation in
the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, B
cells, monocytes, dendritic cells and most thymocytes. Consistent with the presence of ITIM motifs, LAIR1 inhibits IL-2 and IFN-gamma production by CD4+ T cells, and reduces IgG and IgE production by B cells. LAIR1 is known to bind to collagens -I, -II, -III, and XVII. The
extracellular domain of human LAIR1 shares 40% aa identity with that of
the mouse protein.
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