Preparation and Storage
The Chk1 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle progression. In response to genotoxic stress, Chk1 is phosphorylated by ATM or ATM-related kinases. In turn, Chk1 phosphorylates downstream effectors, such as p53 or the Cdc25 phosphatases to halt cell cycle progression and allow time for repair of incurred damage.
Checkpoint Kinase 1
Entrez Gene IDs:
1111 (Human); 12649 (Mouse); 140583 (Rat)
CHEK1; Checkpoint, S. pombe, homolog of, 1; CHK1 (checkpoint, S.pombe) homolog; CHK1 checkpoint homolog (S. pombe); CHK1serine/threonine-protein kinase Chk1; EC 2.7.11; EC 220.127.116.11
Related Research Areas
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Showing Results 1 - 1 of 1
- VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.
Authors: Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V
J. Clin. Invest., 2011;121(0):3071-87.
Sample Type: Cell Lysates