Background: Chk1
  • Long Name:
    Checkpoint Kinase 1
  • Entrez Gene IDs:
    1111 (Human); 12649 (Mouse); 140583 (Rat)
  • Alternate Names:
    Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1 (checkpoint, S.pombe) homolog; CHK1 checkpoint homolog (S. pombe); CHK1serine/threonine-protein kinase Chk1; EC 2.7.11; EC 2.7.11.1
Preparation and Storage
  • Stability & Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: Chk1
The Chk1 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle progression. In response to genotoxic stress, Chk1 is phosphorylated by ATM or ATM-related kinases. In turn, Chk1 phosphorylates downstream effectors, such as p53 or the Cdc25 phosphatases to halt cell cycle progression and allow time for repair of incurred damage.
  • Long Name:
    Checkpoint Kinase 1
  • Entrez Gene IDs:
    1111 (Human); 12649 (Mouse); 140583 (Rat)
  • Alternate Names:
    Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1 (checkpoint, S.pombe) homolog; CHK1 checkpoint homolog (S. pombe); CHK1serine/threonine-protein kinase Chk1; EC 2.7.11; EC 2.7.11.1
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Showing Results 1 - 1 of 1

  1. VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.
    Authors: Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V
    J. Clin. Invest., 2011;121(0):3071-87.
    Species: Mouse
    Sample Type: Cell Lysates

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