Human P2Y1/P2RY1 PE-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry View Larger

Detection of P2Y1/P2RY1 in HEK293 Human Cell Line Transfected with Human P2Y1/P2RY1 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human P2Y1/P2RY1 and eGFP were stained with (A) Mouse Anti-Human P2Y1/P2RY1 PE-conjugated Monoclonal Antibody (Catalog # FAB9290P) or (B) isotype control antibody (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.

Preparation and Storage

Background: P2Y1/P2RY1

P2RY1 belongs to the family of G protein-coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. P2RY1 functions as a receptor for extracellular ATP and ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C. ADP binding also may lead to a change in platelet shape and possible platelet aggregation.

Product Datasheets

Related Research Areas

• GPCRs in Blood Pressure Regulation
• Microglia Activation
• Neurotransmitter Receptors on Endothelial Cells
• Platelet GPCRs
• Platelet Purinergic Receptors
• Purinergic (P2Y) Receptors