Human Phospho-p70 S6 Kinase (T389) DuoSet IC ELISA
Human Phospho-p70 S6 Kinase (T389) DuoSet IC ELISA Summary
* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.
Preparation and Storage
Background: p70 S6 Kinase
p70 S6 kinase is a Ser/Thr kinase activated by such mitogens as EGF, IGF-I, and insulin. The S6 protein of the 40S ribosomal subunit is a major substrate of p70 S6 kinase, and its phosphorylation upregulates the translation of mRNAs containing an oligopyrimidine tract at their transcriptional start site. The activity of p70 S6 kinase is controlled by multiple phosphorylation events, with phosphorylation at T229 by PDK1 and T389 by mTOR most critical for kinase function.
Citations for Human Phospho-p70 S6 Kinase (T389) DuoSet IC ELISA
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Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
Proc Natl Acad Sci USA, 2016;0(0):.
Sample Types: Cell Lysates
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Authors: Hashimoto T, Perlot T, Rehman A
Sample Types: Tissue Homogenates
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