Human Serpin G1/C1 Inhibitor Biotinylated Antibody

Catalog # Availability Size / Price Qty
BAF2488
Product Details
Citations (2)
FAQs
Supplemental Products
Reviews

Human Serpin G1/C1 Inhibitor Biotinylated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Serpin G1 in Western blots. In this format, less than 3% cross‑reactivity with recombinant human (rh) Serpin A1, A3, A4, A5, C1, F1, F2, I1, I2, rmSerpin D1, and rmSerpin F2 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Human plasma-derived Serpin G1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Human Serpin G1/C1 Inhibitor (Catalog # 2488-PI)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Serpin G1/C1 Inhibitor

As a member of the serpin superfamily of serine protease inhibitors, Serpin G1/C1 inhibitor is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. In addition, it inhibits plasma kallikrein and coagulation factor XIIa, two serine proteases involved in the processing of kininogen to release bradykinin. Therefore, it plays an important role in regulating activation of both the complement and contact systems (1). Serpin G1 deficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa (2). The deduced amino acid sequence of human Serpin G1 precursor consists of 500 residues with a signal peptide. The mature protein of 478 amino acid residues is heavily glycosylated (1).

References
  1. Davis, A.E. III et al. (1993) Methods Enzymol. 223:97.
  2. Davis, A.E. III (2004) Drug News Perspect. 17:439.
Entrez Gene IDs
710 (Human)
Alternate Names
C1 Inhibitor; C1IN; C1INH; C1NH; HAE1; HAE2; Serpin G1; SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

Product Datasheets

Citations for Human Serpin G1/C1 Inhibitor Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort.
    Authors: Zhang Y, Vernooij F, Ibrahim I, Ooi S, Gijsberts C, Schoneveld A, Sen K, den Ruijter H, Timmers L, Richards A, Jong C, Mazlan I, Wang J, Lam C, de Kleijn D
    PLoS ONE, 2016;11(1):e0148073.
    Species: Human
    Sample Types: Plasma
    Applications: ELISA Development
  2. Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating c1 inhibitor.
    Authors: Zhou, Zhao-Hua, Rajabi, Mohsen, Chen, Trina, Karnaukhova, Elena, Kozlowski, Steven
    PLoS ONE, 2012;7(10):e47296.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance

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