Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

ELISA Detection, ELISA Development, Surface Plasmon Resonance

Label

Biotin

Antibody Source

Polyclonal Goat IgG
View all Serpin G1/C1 Inhibitor Primary Antibodies »

Product Specifications

Immunogen

Human plasma-derived Serpin G1

Specificity

Detects human Serpin G1 in Western blots. In this format, less than 3% cross‑reactivity with recombinant human (rh) Serpin A1, A3, A4, A5, C1, F1, F2, I1, I2, rmSerpin D1, and rmSerpin F2 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Serpin G1/C1 Inhibitor Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Human Serpin G1/C1 Inhibitor (Catalog # 2488-PI)

Reviewed Applications

Read 1 review rated 5 using BAF2488 in the following applications:

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Serpin G1/C1 Inhibitor

As a member of the serpin superfamily of serine protease inhibitors, Serpin G1/C1 inhibitor is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. In addition, it inhibits plasma kallikrein and coagulation factor XIIa, two serine proteases involved in the processing of kininogen to release bradykinin. Therefore, it plays an important role in regulating activation of both the complement and contact systems (1). Serpin G1 deficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa (2). The deduced amino acid sequence of human Serpin G1 precursor consists of 500 residues with a signal peptide. The mature protein of 478 amino acid residues is heavily glycosylated (1).

References

  1. Davis, A.E. III et al. (1993) Methods Enzymol. 223:97.
  2. Davis, A.E. III (2004) Drug News Perspect. 17:439.

Alternate Names

C1 Inhibitor

Entrez Gene IDs

710 (Human)

Gene Symbol

SERPING1

Additional Serpin G1/C1 Inhibitor Products

Product Documents for Human Serpin G1/C1 Inhibitor Biotinylated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Serpin G1/C1 Inhibitor Biotinylated Antibody

For research use only

Citations for Human Serpin G1/C1 Inhibitor Biotinylated Antibody

Customer Reviews for Human Serpin G1/C1 Inhibitor Biotinylated Antibody (1)

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  • Human Serpin G1/C1 Inhibitor Biotinylated Antibody
    Name: Anonymous
    Application: Western Blot
    Sample Tested: Recombinant protein
    Species: Human
    Verified Customer | Posted 09/10/2019
    Human Serpin G1/C1 Inhibitor Biotinylated Antibody BAF2488

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