Human Siglec-5/Siglec-14 Fluorescein-conjugated Antibody
Human Siglec-5/Siglec-14 Fluorescein-conjugated Antibody Summary
Accession # O15389
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Siglec‑5/Siglec‑14 in Human Monocytes by Flow Cytometry. Human monocytes were stained with Mouse Anti-Human Siglec‑5/Siglec‑14 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB10721F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Siglecs (Sialic acid binding Ig-like Lectins) are a subgroup of the immunoglobulin superfamily that interact with sialic acids in glycoproteins and glycolipids. Siglec-5, also known as CD170, binds to alpha-2,3- and alpha-2,6-linked sialic acid with similar affinity. It occurs as a disulfide-linked dimer of approximately 140 kDa with the highest expression levels in monocytes and neutrophils. Siglec-5 has an inhibitory motif within its cytoplasmic domain. Siglec-14 is an activating receptor that shares 99.5% aa sequence identity with Siglec-5 through the first two extracellular Ig domains and displays a similar glycan binding preference.
Citations for Human Siglec-5/Siglec-14 Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery.
Authors: Yang, Mingli, Jiang, Guohua, Li, Wenjing, Qiu, Kai, Zhang, Min, Carter, Christop, Al-Quran, Samer Z, Li, Ying
J Hematol Oncol, 2014;7(0):5.
Sample Types: Whole Cells
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Authors: Ali S, Fong J, Carlin A, Busch T, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A
J Exp Med, 2014;211(6):1231-42.
Sample Types: Whole Cells
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