Human THSD1 PE-conjugated Antibody

FAB5178P has been discontinued. View all THSD1 products.
  
  • Species Reactivity
    Human
  • Specificity
    Detects human TSHD1.
  • Source
    Monoclonal Mouse IgG1 Clone # 541213
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human THSD1 isoform 2
    Glu25-Ile361
    Accession # NP_954872
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of THSD1 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells was stained with Mouse Anti-Human THSD1 PE‑conjugated Monoclonal Antibody (Catalog # FAB5178P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: THSD1
THSD1 (Thrombospondin type 1 Domain-containing protein 1), also known as TMTSP, is a 90‑100 kDa type I transmembrane protein that is reminiscent of Unc5h proteins. It is expressed on embryonic endothelial and hematopoietic stem cells, and may be involved in cell-cell interactions. Mature human THSD1 (SwissProt #: Q9NS62) contains a 389 amino acid (aa) extracellular domain (ECD) (aa 25‑413) and a 418 aa cytoplasmic region (aa 435‑852). The ECD possesses one TSP type-1 domain (aa 340‑393). There is one potential alternate start site at Met380, and two splice variants, isoform 2 of which shows a deletion of aa 341‑393 (the isoform found in NP_954872 and used here to generate this monoclonal), and isoform 3 that shows a 36 aa substitution for aa 394‑857, generating a soluble form. Over aa 25‑361 of isoform 2, human THSD1 is 76% aa identical to mouse THSD1.
  • Long Name:
    Thrombospondin, Type I, Domain Containing 1
  • Entrez Gene IDs:
    55901 (Human); 56229 (Mouse); 364630 (Rat)
  • Alternate Names:
    thrombospondin type-1 domain-containing protein 1; thrombospondin, type I, domain 1; thrombospondin, type I, domain containing 1,4833423O18Rik; THSD1; TMTSP; TMTSPMGC74971; Transmembrane molecule with thrombospondin module; UNQ3010
Related Research Areas

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