Catalog Number: 5235
Biological Activity
Potent and selective N-type Ca2+ channel blocker (IC50 ~ 60 nM); selectively and reversibly blocks N-type Ca2+ channels. Does not block T-type Ca2+ channels, K+ channels or Na+ channels. Exhibits analgesic effects in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge: 1-16,8-21,15-36)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena.
    Deng et al.
    Neuropharmacology, 2014;79:657
  2. Venomics of the spider Ornithoctonus huwena based on transcriptomic versus proteomic analysis.
    Jiang et al.
    Comp.Biochem.Physiol.Part D Genomics Proteomics, 2010;5:81
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