Catalog Number: 0837
Chemical Name: 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid
Biological Activity
Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor.
    Arakawa et al.
    Br.J.Pharmacol., 1993;110:127
  2. Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity.
    Cao et al.
    Eur.J.Pharmacol., 2004;485:317
  3. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605.
    Brewster et al.
    Prostaglandins, 1988;36:173

The citations listed below are publications that use Tocris products. Selected citations for ICI 192,605 include:

1 Citations: Showing 1 - 1

  1. Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein.
    Authors: Daray Et al.
    Naunyn Schmiedebergs Arch Pharmacol 2003;139:1409

Have you used ICI 192,605?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee


Customer Information