Catalog Number: 0837
Chemical Name: 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid
Biological Activity
Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor.
    Arakawa et al.
    Br.J.Pharmacol., 1993;110:127
  2. Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity.
    Cao et al.
    Eur.J.Pharmacol., 2004;485:317
  3. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605.
    Brewster et al.
    Prostaglandins, 1988;36:173

The citations listed below are publications that use Tocris products. Selected citations for ICI 192,605 include:

Showing Results 1 - 1 of 1

  1. Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein.
    Authors: Daray Et al.
    Naunyn Schmiedebergs Arch Pharmacol
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