Catalog Number: 0832
Chemical Name: N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-N'-phenylurea
Biological Activity
β-adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.
Technical Data
  • M.Wt:
    354.41
  • Formula:
    C19H22N4O3
  • Solubility:
    Soluble in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    53671-71-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. β-Adrenergic Receptors.
    Mai
    Comprehensive Medicinal Chemistry. Ed. Hansch., 1990;3:187
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ICI 89406 include:

2 Citations: Showing 1 - 2
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  1. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.
    Authors: Mistry Et al.
    J Med Chem 2013;56:3852
  2. Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
    Authors: Kaya Et al.
    J Pharmacol Exp Ther 2009;329:350

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