Chemical Name: N,N,H,-Trimethyl-5-[(tricyclo[220.127.116.11,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide
Biological Activity Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluR2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.
Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT
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