Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+
-permeable) receptors over GluR2-containing receptors (IC50
values are 2.6 and 1102 μ
M, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo
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All Tocris products are intended for laboratory research use only.
Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460.
Buldakova et al.
Brain Res., 1999;846:52
Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.
Gittis et al.
Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors.
Schlesinger et al.
The citations listed below are publications that use Tocris products. Selected citations for IEM 1460 include:
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