IEM 1460 (CAS 121034-89-7): R&D Systems
Catalog Number: 1636
Chemical Name: N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide
Biological Activity
Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluR2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.
Technical Data
  • M.Wt:
    454.33
  • Formula:
    C19H37N2Br.HBr
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    121034-89-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460.
    Buldakova et al.
    Brain Res., 1999;846:52
  2. Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.
    Gittis et al.
    J.Neurosci., 2012;31:15727
  3. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors.
    Schlesinger et al.
    Br.J.Pharmacol., 2005;145:656
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IEM 1460 include:

14 Citations: Showing 1 - 10
Filter your results:

  1. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci 2016;36:622
  2. Inhibition of spinal Ca(2+)-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects.
    Authors: Kopach Et al.
    Front.Cell.Neurosci. 2016;10:50
  3. Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.
    Authors: Liu Et al.
    Mol Brain 2015;8:76
  4. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    J Pharmacol Exp Ther 2015;5:14099
  5. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
    Authors: Höft Et al.
    Philos Trans R Soc Lond B Biol Sci 2014;369:20130602
  6. Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
    Authors: Cabañero Et al.
    Neuropsychopharmacology 2013;38:1472
  7. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms.
    Authors: Chen Et al.
    PLoS Negl Trop Dis 2013;347:765
  8. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci 2012;32:8127
  9. Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites.
    Authors: Colgan Et al.
    J Neurosci 2012;32:15737
  10. Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat.
    Authors: Case Et al.
    PLoS One 2011;6:e20756
  11. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
    Authors: Kopach Et al.
    Pain 2011;152:912
  12. Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord.
    Authors: Santos Et al.
    PLoS One 2009;4:e8047
  13. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci 2009;29:9668
  14. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
    Authors: Guire Et al.
    Sci Rep 2008;28:6000
Expand to show all 14 Citations

Have you used IEM 1460?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information