IEM 1460

Catalog # Availability Size / Price Qty
1636/10
1636/50
IEM 1460 | CAS No. 121034-89-7 | AMPA Receptor Blockers
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Description: Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

Chemical Name: N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide

Purity: ≥98%

Product Details
Citations (16)
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Reviews

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluA2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.

Technical Data

M.Wt:
454.33
Formula:
C19H37N2Br.HBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
121034-89-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for IEM 1460

The citations listed below are publications that use Tocris products. Selected citations for IEM 1460 include:

16 Citations: Showing 1 - 10

  1. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
    Authors: Purkey Et al.
    Cell Rep  2018;25:974
  2. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons.
    Authors: Suyama Et al.
    Elife  2017;6
  3. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci  2016;36:622
  4. Inhibition of spinal Ca(2+)-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects.
    Authors: Kopach Et al.
    Front.Cell.Neurosci.  2016;10:50
  5. Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.
    Authors: Liu Et al.
    Mol Brain  2015;8:76
  6. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    J Pharmacol Exp Ther  2015;5:14099
  7. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
    Authors: Höft Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130602
  8. Pain after discontinuation of mor. treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
    Authors: Cabañero Et al.
    Neuropsychopharmacology  2013;38:1472
  9. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms.
    Authors: Chen Et al.
    PLoS Negl Trop Dis  2013;347:765
  10. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci  2012;32:8127

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