IEM 1460

  ( 14 citations )    
Product Datasheet
Catalog Number:1636
Chemical Name:N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluR2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.
Technical Data
  • M.Wt:
    454.33
  • Formula:
    C19H37N2Br.HBr
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    121034-89-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for IEM 1460 include:

14 Citations: Showing 1 - 10
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  1. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci  2016;36:622
  2. Inhibition of spinal Ca(2+)-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects.
    Authors: Kopach Et al.
    Front.Cell.Neurosci.  2016;10:50
  3. Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.
    Authors: Liu Et al.
    Mol Brain  2015;8:76
  4. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    J Pharmacol Exp Ther  2015;5:14099
  5. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
    Authors: Höft Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130602
  6. Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
    Authors: Cabañero Et al.
    Neuropsychopharmacology  2013;38:1472
  7. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms.
    Authors: Chen Et al.
    PLoS Negl Trop Dis  2013;347:765
  8. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci  2012;32:8127
  9. Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites.
    Authors: Colgan Et al.
    J Neurosci  2012;32:15737
  10. Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat.
    Authors: Case Et al.
    PLoS One  2011;6:e20756
  11. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
    Authors: Kopach Et al.
    Pain  2011;152:912
  12. Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord.
    Authors: Santos Et al.
    PLoS One  2009;4:e8047
  13. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci  2009;29:9668
  14. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
    Authors: Guire Et al.
    Sci Rep  2008;28:6000
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