IQ 1S

Catalog # Availability Size / Price Qty
5575/10
5575/50
Cat.No. 5575 - IQ 1S | C15H8N3NaO | CAS No. 1421610-21-0
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Description: JNK inhibitor; anti-inflammatory; also NO donor

Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt

Product Details
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Biological Activity

JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.

Technical Data

Formula:
C15H8N3NaO
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1421610-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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