Catalog Number: 5575
Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
Biological Activity
JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.
Technical Data
  • M.Wt:
    269.23
  • Formula:
    C15H8N3NaO
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    1421610-21-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
    Schepetkin et al.
    Mol.Pharmacol., 2012;81:832
  2. Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor.
    Schepetkin et al.
    J.Pharmacol.Exp.Ther., 2015;353:505
  3. A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice.
    Atochin et al.
    Neurosci.Lett., 2016;618:45

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