Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
Biological Activity JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.
Soluble to 20 mM in DMSO with gentle warming
Store at -20°C
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