IRL-2500

  ( 1 citations )    
Product Datasheet
Catalog Number:1838
Chemical Name:N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan
Product Details
Citations (1)
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Reviews
Biological Activity
Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
Technical Data
  • M.Wt:
    573.69
  • Formula:
    C36H35N3O4
  • Solubility:
    Soluble to 75 mM in 1eq. NaOH with gentle warming
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    169545-27-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for IRL-2500 include:

1 Citations: Showing 1 - 1

  1. Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes.
    Authors: Merlen Et al.
    J Mol Cell Cardiol  2013;62:189

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