Catalog Number: 1838
Chemical Name: N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan
Biological Activity
Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in 1eq. NaOH with gentle warming
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.
    Balwierczak et al.
    J.Cardiovasc.Pharmacol., 1995;26:S393
  2. Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ETB receptors.
    Leung et al.
    J.Cardiovasc.Pharmacol., 2002;39:533
  3. Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats.
    Webb et al.
    J.Cardiovasc.Pharmacol., 1995;26:S389
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