Biological Activity Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
Soluble to 75 mM in 1eq. NaOH with gentle warming
Desiccate at RT
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