L-(-)-threo-3-Hydroxyaspartic acid (CAS 7298-99-9): R&D Systems
Catalog Number: 0183
Alternate Names: L-threo-β-Hydroxyaspartic acid
Biological Activity
Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    149.1
  • Formula:
    C4H7NO5
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    7298-99-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate.
    Johnston et al.
    J.Neurochem., 1980;34:241
  2. Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.
    McBean and Roberts
    J.Neurochem., 1985;44:247
  3. (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
    Nakamura et al.
    Neuropharmacology, 1993;32:833

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