Catalog Number: 1698
Chemical Name: 1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
Biological Activity
Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. pA2 values are 8 - 8.4 in guinea pig smooth muscle; IC50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo.
Technical Data
  • M.Wt:
    373.85
  • Formula:
    C21H21ClFNO2
  • Solubility:
    Soluble to 50 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    103253-15-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic acid); a potent, selective thomboxane / prostaglandin endoperoxide antagonist.
    Hall et al.
    Eur.J.Pharmacol., 1987;135:193
  2. The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias.
    Wainright and Parratt
    J.Cardiovasc.Pharmacol., 1988;12:264
  3. Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles.
    Ogletree and Allen
    J.Pharmacol.Exp.Ther., 1992;260:789
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-655,240 include:

1 Citations: Showing 1 - 1

  1. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res 2009;104:228

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