Potent and selective thromboxane A2
/prostaglandin endoperoxide receptor antagonist. pA2
values are 8 - 8.4 in guinea pig smooth muscle; IC50
= 7 nM for inhibition of human platelet aggregation. Orally active in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic acid); a potent, selective thomboxane / prostaglandin endoperoxide antagonist.
Hall et al.
The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias.
Wainright and Parratt
Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles.
Ogletree and Allen
The citations listed below are publications that use Tocris products. Selected citations for L-655,240 include:
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